Understanding and Modulating the Innate Immune Response to Address the Immunogenicity of AAVs

Time: 9:45 am
day: Day Two

Details:

• AAV injection causes systemic innate immune response marked by cytokine response and Myd88 over-expression
• Modulating Myd88 as a key node in innate immunity impacts the adaptive immunity to AAV
• Engineering Myd88 regulators can be a novel tool to control AAV immunogenicity in vivo

Speakers:

Samira Kiani Samira Kiani is an associate professor of pathology and bioengineering at University of Pittsburgh and cofounder and CEO of GenexGen, Inc. Her work combines synthetic Read more