Manuela Braun

Company: Bayer

Job title: Senior Scientific Expert - Preclinical Development of Gene & Cell Therapy Products

Seminars:

Fit-For-Purpose Support of Pre-existing Antibody Assessment From Use in Preclinical Development to Use as Companion Diagnostic 3:15 pm

Purpose of bioanalytical and diagnostic assay How to set an appropriate cut-off for patient selection? Characterization and validation of methods Assay Journey: from preclinical use to use as companion diagnosticRead more

day: Day 1 PM

Detecting Pre-Existing Antibodies to AAV Gene Therapies 11:00 am

One of the inherent challenges to effective AAV gene therapy treatment is the prior exposure and neutralizing antibody (NAb) generation in a large number of target populations. The methods used for testing for seropositivity prior to transfer remains a hotly-debated topic, with no universal test or titer currently deployed as an industry standard for detecting…Read more

day: Pre-Conference Day