Workshop: Optimizing Vector Design & Manufacturing to Minimize Immunogenicity – A CMC Perspective
Time: 1:15 pm
day: Pre-conference day
Details:
This interactive workshop will explore how improvements in vector engineering, production methods, and analytical characterization can reduce immune responses, enhance therapeutic efficacy, and streamline regulatory approval.
In this workshop, you will:
• Understand how vector design influences immune responses and identify engineering strategies to reduce immunogenicity
• Evaluate manufacturing and purification approaches to minimize contaminants and immunostimulatory byproducts
• Explore how capsid modifications, codon optimization, and payload engineering can enhance vector stealth and immune evasion
• Discuss analytical techniques to characterize vector-associated immunogenicity and ensure CMC strategies align with regulatory expectations
• Hear case studies on how leading companies are refining vector production to improve safety and efficacy while maintaining scalability
