Shari Gordon

Company: AskBio

Job title: Senior Director - Immunology

Seminars:

Evaluating the Impact of Genetic Diversity and Immunogenicity on the Efficacy of AAV Gene Therapy 1:30 pm

Outlining key reasons for the lack of predictive murine models Using genetically diverse collaborative cross (CC) mice to elucidate drug toxicity and host-pathogen factors that lead to infection persistence or clearance Administering an AAV8 vector to 16 strains of CC mice and evaluating the effects of genetic diversity and adaptive immune responses on efficacyRead more

day: Day 1 Track A PM

Panel Discussion: Aligning Immunomodulation Regimens with Overall Development Goals 9:00 am

Outlining early your desired downstream immune response to better inform your regimen selection Key considerations in AAV vector types for this selection process Linking patient population characteristics to the regimenRead more

day: Day One