Immunogenicity Profile in Wild-Type Ferrets After Treatment With SP-101 & Doxorubicin: Inhalation Delivery of AAV Gene Therapy for the Treatment of Cystic Fibrosis

Time: 12:30 pm
day: Day 1 Tacks 1 AM

Details:

  • Sharing the impact of inhalation delivery on the post-dose capsid neutralizing antibody (cell-based assay) profile
  • Implementation of a post-dose capsid total antibody (IgG) response and the decision-making process leading to a screen and titer strategy
  • Evaluation of ferret T-cell responses to the capsid and transgene measured via ELISPOT, the implications of measuring no or low responses

Speakers: