Immune Response to Long-Term CAS9 Expression in Mice & Nhps in the Context of Crispr-Gndm® Mediated Gene Modulation

Time: 4:30 pm
day: Day One


  • CRISPR/Cas9-mediated in-vivo gene editing offers great potential to treat several genetic disorders
  • Conventional gene editing mediated through DNA strand breaks leads to offtarget gene changes and sometimes cause fatal consequences
  • Our proprietary CRISPR-GNDM® (Guide Nucleotide-Mediated Modulation) platform (aka CRISPRa/i), modulates gene expression without DNA strand breaks has great potential to overcome this hurdle