Applications of Directed Evolution Toward Reducing The Immunogenicity Risk of Transgenes

Time: 12:00 pm
day: Day 2 Tracks 1 AM


  • Transgenes may lead to neutralizing antibodies that impact their safety and efficacy in patients
  • Immunogenicity risk of transgenes can be reduced by increasing protein stability or removing putative T cell epitopes
  • We discuss applications of the CodeEvolver® directed evolution platform toward engineering transgenes with reduced immunogenicity risk profiles for lysosomal storage diseases